Recent Publications

Sensory representations and pupil-indexed listening effort provide complementary contributions to multi-talker speech intelligibility

McHaney JR, Hancock KE, Polley DB, Parthasarathy A

Article Scientific Reports 14(1):30882

Auditory circuits: Watchmen of the sleeping brain

Polley DB, Chambers AR

Review Current Biology 34(20):R924-R926

2023

Potentiation of cholinergic and corticofugal inputs to the lateral amygdala in threat learning

Asokan MM, Watanabe Y, Kimchi EY, Polley DB

Article Cell Reports 42(10):113167

Asymmetric hearing thresholds are associated with hyperacusis in a large clinical population

Jahn KN, Polley DB

Article Hearing Research 437:108854

New revelations from the zone of uncertainty

Asokan MM, Polley DB

Review Neuron 111(5):601-603

Cortical contributions to the perception of loudness and hyperacusis

McGill M, Kremer C, Stecyk KS, Clayton KK, Skerleva D, Hancock KE, Kujawa SG, Polley DB

Preprint bioRxiv 2023.03.24.534013

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2022

Predicting neural deficits in sensorineural hearing loss from word recognition scores

Grant KJ, Parthasarathy A, Vasilkov V, Caswell-Midwinter B, Freitas ME, de Gruttola V, Polley DB, Liberman MC, Maison SF

Article Scientific Reports 12(1):8929

Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms

Jahn KN, Hancock KE, Maison SF, Polley DB

Article JASA Express Letters 2(6):064403

Neural signatures of auditory hypersensitivity following acoustic trauma

McGill M, Hight AE, Watanabe YL, Parthasarathy A, Cai D, Clayton K, Hancock KE, Takesian A, Kujawa SG, Polley DB

Article eLife 11:e80015

Automatic identification of tinnitus malingering based on overt and covert behavioral responses during psychoacoustic testing

Smalt CJ, Sugai JA, Koops EA, Jahn KN, Hancock KE, Polley DB

Article npj Digital Medicine 5(1):127

The promise of low-tech intervention in a high-tech era: Remodeling pathological brain circuits using behavioral reverse engineering

Polley DB, Schiller D

Review Neuroscience & Biobehavioral Reviews 137:104652

2021

Inverted central auditory hierarchies for encoding local intervals and global temporal patterns

Asokan MM, Williamson RS, Hancock KE, Polley DB

Article Current Biology 31(8):1762-1770.e4

Auditory Corticothalamic Neurons Are Recruited by Motor Preparatory Inputs

Clayton KK, Williamson RS, Hancock KE, Tasaka GI, Mizrahi A, Hackett TA, Polley DB

Article Current Biology 31(2):310-321.e5

Cochlear neural degeneration disrupts hearing in background noise by increasing auditory cortex internal noise

Resnik J, Polley DB

Article Neuron 109(6):984-996.e4

A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes

Robert B, Kimchi EY, Watanabe Y, Chakoma T, Jing M, Li Y, Polley DB

Article eLife 10:e69514

Behavioral Approaches to Study Top-Down Influences on Active Listening

Clayton KK, Asokan MM, Watanabe Y, Hancock KE, Polley DB

Review Frontiers in Neuroscience 15:666627

2020

Fluctuations in Subjective Tinnitus Ratings Over Time: Implications for Clinical Research

Chen JX, Whitton JP, Parthasarathy A, Hancock KE, Polley DB

Article Otology & Neurotology 41(9):e1167-e1173

Audiometric Predictors of Bothersome Tinnitus in a Large Clinical Cohort of Adults With Sensorineural Hearing Loss

Lewis RM, Jahn KN, Parthasarathy A, Goedicke WB, Polley DB

Article Otology & Neurotology 41(4):e414-e421

Bottom-up and top-down neural signatures of disordered multi-talker speech perception in adults with normal hearing

Parthasarathy A, Hancock KE, Bennett K, DeGruttola V, Polley DB

Article eLife 9:e51419

Data-driven segmentation of audiometric phenotypes across a large clinical cohort

Parthasarathy A, Romero Pinto S, Lewis RM, Goedicke W, Polley DB

Article Scientific Reports 10(1):6704

Cellular and Widefield Imaging of Sound Frequency Organization in Primary and Higher Order Fields of the Mouse Auditory Cortex

Romero S, Hight AE, Clayton KK, Resnik J, Williamson RS, Hancock KE, Polley DB

Article Cerebral Cortex 30(3):1603-1622

2019

Synergistic Transcriptional Changes in AMPA and GABA(A) Receptor Genes Support Compensatory Plasticity Following Unilateral Hearing Loss

Balaram P, Hackett TA, Polley DB

Article Neuroscience 407:108-119

The Cholinergic Basal Forebrain Links Auditory Stimuli with Delayed Reinforcement to Support Learning

Guo W, Robert B, Polley DB

Article Neuron 103(6):1164-1177.e6

Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders

Nist-Lund CA, Pan B, Patterson A, Asai Y, Chen T, Zhou W, Zhu H, Romero S, Resnik J, Polley DB, Géléoc GS, Holt JR

Article Nature Communications 10(1):236

Optimizing optogenetic stimulation protocols in auditory corticofugal neurons based on closed-loop spike feedback

Vila CH, Williamson RS, Hancock KE, Polley DB

Article Journal of Neural Engineering 16(6):066023

Parallel pathways for sound processing and functional connectivity among layer 5 and 6 auditory corticofugal neurons

Williamson RS, Polley DB

Article eLife 8:e42974

2018

Sensory overamplification in layer 5 auditory corticofugal projection neurons following cochlear nerve synaptic damage

Asokan MM, Williamson RS, Hancock KE, Polley DB

Article Nature Communications 9(1):2468

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents

Gao X, Tao Y, Lamas V, Huang M, Yeh WH, Pan B, Hu YJ, Hu JH, Thompson DB, Shu Y, Li Y, Wang H, Yang S, Xu Q, Polley DB, Liberman MC, Kong WJ, Holt JR, Chen ZY, Liu DR

Article Nature 553(7687):217-221